منابع مشابه
Impact of Chronic HIV/SIV Infection on T Follicular Helper Cell Subsets and Germinal Center Homeostasis
The discovery of broad and potent HIV-1 neutralizing antibodies (bNAbs) has renewed optimism for developing an effective vaccine against HIV-1. The generation of most bNAbs requires multiple rounds of B cell receptor affinity maturation, suggesting a crucial role of follicular helper T (Tfh) cells in their production. However, less than 1% of HIV-infected patients develop bNAbs that arise late ...
متن کاملHIV-Infected Spleens Present Altered Follicular Helper T Cell (Tfh) Subsets and Skewed B Cell Maturation
Follicular helper T (Tfh) cells within secondary lymphoid organs control multiple steps of B cell maturation and antibody (Ab) production. HIV-1 infection is associated with an altered B cell differentiation and Tfh isolated from lymph nodes of HIV-infected (HIV+) individuals provide inadequate B cell help in vitro. However, the mechanisms underlying this impairment of Tfh function are not full...
متن کاملFollicular regulatory T cells impair follicular T helper cells in HIV and SIV infection
Human and simian immunodeficiency viruses (HIV and SIV) exploit follicular lymphoid regions by establishing high levels of viral replication and dysregulating humoral immunity. Follicular regulatory T cells (TFR) are a recently characterized subset of lymphocytes that influence the germinal centre response through interactions with follicular helper T cells (TFH). Here, utilizing both human and...
متن کاملCd4+ T Cell Subsets during Virus Infection
To analyze the antiviral protective capacities of CD4(+) T helper (Th) cell subsets, we used transgenic T cells expressing an I-A(b)-restricted T cell receptor specific for an epitope of vesicular stomatitis virus glycoprotein (VSV-G). After polarization into Th1 or Th2 effectors and adoptive transfer into T cell-deficient recipients, protective capacities were assessed after infection with dif...
متن کاملInfluence of CD38/PD1 co-expression on T cell subsets in HIV-TB co-infection
Background Excessive immune activation as indicated by CD38 expression is a characteristic feature of HIV progression. There are growing evidences suggesting that immune inhibitory signals such as PD1 expression also play an important role in progression of the disease. However, the relationship between these positive (CD38) and negative (PD1) immune signals on T cells in HIV-TB co-infection ha...
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ژورنال
عنوان ژورنال: Current Opinion in HIV and AIDS
سال: 2019
ISSN: 1746-630X
DOI: 10.1097/coh.0000000000000525